Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

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A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial houston texans funko pop activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the fresh n clean cream rinse minimum inhibitory concentration (MIC90) in μg/mL.Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.